Very interesting report on what could be a very useful compound…for those inclined, of course.
LSD is a classic and well known psychedelic drug known to be well tolerated physiologically by almost all users. Until recently very few analogues existed due to the relative difficulty of synthesising the lysergic acid backbone but in recent years constant scheduling of lower-hanging fruit has forced innovation in the novel psychoactive substance industry and a number of lysergamides have emerged as a result.
1-Acetyl-LSD (ALD-52) is somewhat notorious for its sale as “Orange Sunshine Acid” in California in the 1960s but has remained mysterious due to the theory that it might degrade to LSD combined with the slightly increased synthetic complexity putting off would-be chemists.
Despite being used to convict the manufacturers, the scientific principle behind this theory is incredibly unstable, with the acetyl group being used in laboratories around the world as a protecting group for indoles like LSD. Once attached, the group is resistant to removal…
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